Controlled dehydration, structural flexibility and gadolinium MRI contrast compound binding in the human plasma glycoprotein afamin

Afamin, which is a human blood plasma glycoprotein, a putative multifunctional transporter of hydrophobic molecules and a marker for metabolic syndrome, poses multiple challenges for crystallographic structure determination, both practically and in analysis of the models. Several hundred crystals we...

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Bibliographic Details
Published in:Acta Crystallogr D Struct Biol
Main Authors: Naschberger, Andreas, Juyoux, Pauline, von Velsen, Jill, Rupp, Bernhard, Bowler, Matthew W.
Format: Artigo
Language:Inglês
Published: International Union of Crystallography 2019
Subjects:
Research Papers
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6889915/
https://ncbi.nlm.nih.gov/pubmed/31793901
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S2059798319013500
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