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APPL1 mediates adiponectin-stimulated p38 MAPK activation by scaffolding the TAK1-MKK3-p38 MAPK pathway

The adaptor protein APPL1 mediates the stimulatory effect of adiponectin on p38 mitogen-activated protein kinase (MAPK) signaling, yet the underlying mechanism remains unclear. Here we show that, in C(2)C(12) cells, overexpression or suppression of APPL1 enhanced or suppressed, respectively, adipone...

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Detalhes bibliográficos
Main Authors: Xin, Xiaoban, Zhou, Lijun, Reyes, Caleb M., Liu, Feng, Dong, Lily Q.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3023211/
https://ncbi.nlm.nih.gov/pubmed/20978232
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpendo.00427.2010
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