Balance between MKK6 and MKK3 Mediates p38 MAPK Associated Resistance to Cisplatin in NSCLC

The p38 MAPK signaling pathway has been proposed as a critical mediator of the therapeutic effect of several antitumor agents, including cisplatin. Here, we found that sensitivity to cisplatin, in a system of 7 non-small cell lung carcinoma derived cell lines, correlated with high levels of MKK6 and...

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Main Authors: Galan-Moya, Eva M., de la Cruz-Morcillo, Miguel A., Valero, Maria Llanos, Callejas-Valera, Juan L., Melgar-Rojas, Pedro, Losa, Javier Hernadez, Salcedo, Mayte, Fernández-Aramburo, Antonio, Cajal, Santiago Ramon y., Sánchez-Prieto, Ricardo
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2011
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3229586/
https://ncbi.nlm.nih.gov/pubmed/22164285
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0028406
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