Non-specific protein–DNA interactions control I-CreI target binding and cleavage

Homing endonucleases represent protein scaffolds that provide powerful tools for genome manipulation, as these enzymes possess a very low frequency of DNA cleavage in eukaryotic genomes due to their high specificity. The basis of protein–DNA recognition must be understood to generate tailored enzyme...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Molina, Rafael, Redondo, Pilar, Stella, Stefano, Marenchino, Marco, D’Abramo, Marco, Gervasio, Francesco Luigi, Charles Epinat, Jean, Valton, Julien, Grizot, Silvestre, Duchateau, Phillipe, Prieto, Jesús, Montoya, Guillermo
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Oxford University Press 2012
Pynciau:
Structural Biology
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3413129/
https://ncbi.nlm.nih.gov/pubmed/22495931
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks320
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