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Non-specific protein–DNA interactions control I-CreI target binding and cleavage
Homing endonucleases represent protein scaffolds that provide powerful tools for genome manipulation, as these enzymes possess a very low frequency of DNA cleavage in eukaryotic genomes due to their high specificity. The basis of protein–DNA recognition must be understood to generate tailored enzyme...
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| 主要な著者: | , , , , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Oxford University Press
2012
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3413129/ https://ncbi.nlm.nih.gov/pubmed/22495931 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks320 |
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