Non-specific protein–DNA interactions control I-CreI target binding and cleavage

Homing endonucleases represent protein scaffolds that provide powerful tools for genome manipulation, as these enzymes possess a very low frequency of DNA cleavage in eukaryotic genomes due to their high specificity. The basis of protein–DNA recognition must be understood to generate tailored enzyme...

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Détails bibliographiques
Auteurs principaux: Molina, Rafael, Redondo, Pilar, Stella, Stefano, Marenchino, Marco, D’Abramo, Marco, Gervasio, Francesco Luigi, Charles Epinat, Jean, Valton, Julien, Grizot, Silvestre, Duchateau, Phillipe, Prieto, Jesús, Montoya, Guillermo
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2012
Sujets:
Structural Biology
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3413129/
https://ncbi.nlm.nih.gov/pubmed/22495931
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks320
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