Engineering a Nickase on the Homing Endonuclease I-DmoI Scaffold

Homing endonucleases are useful tools for genome modification because of their capability to recognize and cleave specifically large DNA targets. These endonucleases generate a DNA double strand break that can be repaired by the DNA damage response machinery. The break can be repaired by homologous...

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Veröffentlicht in:J Biol Chem
Hauptverfasser: Molina, Rafael, Marcaida, María José, Redondo, Pilar, Marenchino, Marco, Duchateau, Phillippe, D'Abramo, Marco, Montoya, Guillermo, Prieto, Jesús
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2015
Schlagworte:
Protein Structure and Folding
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4513113/
https://ncbi.nlm.nih.gov/pubmed/26045557
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.658666
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