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Engineering a Nickase on the Homing Endonuclease I-DmoI Scaffold
Homing endonucleases are useful tools for genome modification because of their capability to recognize and cleave specifically large DNA targets. These endonucleases generate a DNA double strand break that can be repaired by the DNA damage response machinery. The break can be repaired by homologous...
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| Publicado no: | J Biol Chem |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4513113/ https://ncbi.nlm.nih.gov/pubmed/26045557 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.658666 |
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