Crystal structure of I-DmoI in complex with its target DNA provides new insights into meganuclease engineering

Homing endonucleases, also known as meganucleases, are sequence-specific enzymes with large DNA recognition sites. These enzymes can be used to induce efficient homologous gene targeting in cells and plants, opening perspectives for genome engineering with applications in a wide series of fields, ra...

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Hlavní autoři: Marcaida, María José, Prieto, Jesús, Redondo, Pilar, Nadra, Alejandro D., Alibés, Andreu, Serrano, Luis, Grizot, Sylvestre, Duchateau, Philippe, Pâques, Frédéric, Blanco, Francisco J., Montoya, Guillermo
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2008
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2579348/
https://ncbi.nlm.nih.gov/pubmed/18974222
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0804795105
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