Molecular basis of engineered meganuclease targeting of the endogenous human RAG1 locus

Homing endonucleases recognize long target DNA sequences generating an accurate double-strand break that promotes gene targeting through homologous recombination. We have modified the homodimeric I-CreI endonuclease through protein engineering to target a specific DNA sequence within the human RAG1...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Main Authors: Muñoz, Inés G., Prieto, Jesús, Subramanian, Sunita, Coloma, Javier, Redondo, Pilar, Villate, Maider, Merino, Nekane, Marenchino, Marco, D'Abramo, Marco, Gervasio, Francesco L., Grizot, Sylvestre, Daboussi, Fayza, Smith, Julianne, Chion-Sotinel, Isabelle, Pâques, Frédéric, Duchateau, Philippe, Alibés, Andreu, Stricher, François, Serrano, Luis, Blanco, Francisco J., Montoya, Guillermo
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2011
Fag:
Structural Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3025557/
https://ncbi.nlm.nih.gov/pubmed/20846960
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkq801
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker