Targeted Gene Therapy of Xeroderma Pigmentosum Cells Using Meganuclease and TALEN™

Xeroderma pigmentosum group C (XP-C) is a rare human syndrome characterized by hypersensitivity to UV light and a dramatic predisposition to skin neoplasms. XP-C cells are deficient in the nucleotide excision repair (NER) pathway, a complex process involved in the recognition and removal of DNA lesi...

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Bibliografiske detaljer
Main Authors: Dupuy, Aurélie, Valton, Julien, Leduc, Sophie, Armier, Jacques, Galetto, Roman, Gouble, Agnès, Lebuhotel, Céline, Stary, Anne, Pâques, Frédéric, Duchateau, Philippe, Sarasin, Alain, Daboussi, Fayza
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2013
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3827243/
https://ncbi.nlm.nih.gov/pubmed/24236034
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0078678
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