Optimized tuning of TALEN specificity using non-conventional RVDs

A key feature when designing DNA targeting tools and especially nucleases is specificity. The ability to control and tune this important parameter represents an invaluable advance to the development of such molecular scissors. Here, we identified and characterized new non-conventional RVDs (ncRVDs)...

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Dettagli Bibliografici
Pubblicato in:Sci Rep
Autori principali: Juillerat, Alexandre, Pessereau, Coline, Dubois, Gwendoline, Guyot, Valérie, Maréchal, Alan, Valton, Julien, Daboussi, Fayza, Poirot, Laurent, Duclert, Aymeric, Duchateau, Philippe
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4311247/
https://ncbi.nlm.nih.gov/pubmed/25632877
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep08150
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