Optimized tuning of TALEN specificity using non-conventional RVDs

A key feature when designing DNA targeting tools and especially nucleases is specificity. The ability to control and tune this important parameter represents an invaluable advance to the development of such molecular scissors. Here, we identified and characterized new non-conventional RVDs (ncRVDs)...

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發表在:Sci Rep
Main Authors: Juillerat, Alexandre, Pessereau, Coline, Dubois, Gwendoline, Guyot, Valérie, Maréchal, Alan, Valton, Julien, Daboussi, Fayza, Poirot, Laurent, Duclert, Aymeric, Duchateau, Philippe
格式: Artigo
語言:Inglês
出版: Nature Publishing Group 2015
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4311247/
https://ncbi.nlm.nih.gov/pubmed/25632877
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep08150
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