Fine and Predictable Tuning of TALEN Gene Editing Targeting for Improved T Cell Adoptive Immunotherapy

Using a TALEN-mediated gene-editing approach, we have previously described a process for the large-scale manufacturing of “off-the-shelf” CAR T cells from third-party donor T cells by disrupting the gene encoding TCRα constant chain (TRAC). Taking advantage of a previously described strategy to cont...

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Pubblicato in:Mol Ther Nucleic Acids
Autori principali: Gautron, Anne-Sophie, Juillerat, Alexandre, Guyot, Valérie, Filhol, Jean-Marie, Dessez, Emilie, Duclert, Aymeric, Duchateau, Philippe, Poirot, Laurent
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Gene & Cell Therapy 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5684446/
https://ncbi.nlm.nih.gov/pubmed/29246309
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtn.2017.10.005
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