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Design of chimeric antigen receptors with integrated controllable transient functions
The ability to control T cells engineered to permanently express chimeric antigen receptors (CARs) is a key feature to improve safety. Here, we describe the development of a new CAR architecture with an integrated switch-on system that permits to control the CAR T-cell function. This system offers t...
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| Pubblicato in: | Sci Rep |
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| Autori principali: | , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Nature Publishing Group
2016
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4707440/ https://ncbi.nlm.nih.gov/pubmed/26750734 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep18950 |
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