Modulation of chimeric antigen receptor surface expression by a small molecule switch

BACKGROUND: Engineered therapeutic cells have attracted a great deal of interest due to their potential applications in treating a wide range of diseases, including cancer and autoimmunity. Chimeric antigen receptor (CAR) T-cells are designed to detect and kill tumor cells that present a specific, p...

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Veröffentlicht in:BMC Biotechnol
Hauptverfasser: Juillerat, Alexandre, Tkach, Diane, Busser, Brian W., Temburni, Sonal, Valton, Julien, Duclert, Aymeric, Poirot, Laurent, Depil, Stéphane, Duchateau, Philippe
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2019
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6610870/
https://ncbi.nlm.nih.gov/pubmed/31269942
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12896-019-0537-3
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