Repurposing endogenous immune pathways to tailor and control chimeric antigen receptor T cell functionality

Endowing chimeric antigen receptor (CAR) T cells with additional potent functionalities holds strong potential for improving their antitumor activity. However, because potency could be deleterious without control, these additional features need to be tightly regulated. Immune pathways offer a wide a...

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Pubblicato in:Nat Commun
Autori principali: Sachdeva, Mohit, Busser, Brian W., Temburni, Sonal, Jahangiri, Billal, Gautron, Anne-Sophie, Maréchal, Alan, Juillerat, Alexandre, Williams, Alan, Depil, Stéphane, Duchateau, Philippe, Poirot, Laurent, Valton, Julien
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6853973/
https://ncbi.nlm.nih.gov/pubmed/31723132
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-13088-3
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