Granulocyte–macrophage colony-stimulating factor inactivation in CAR T-cells prevents monocyte-dependent release of key cytokine release syndrome mediators

Chimeric antigen receptor T-cell (CAR T-cell) therapy has been shown to be clinically effective for managing a variety of hematological cancers. However, CAR T-cell therapy is associated with multiple adverse effects, including neurotoxicity and cytokine release syndrome (CRS). CRS arises from massi...

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Bibliographische Detailangaben
Veröffentlicht in:J Biol Chem
Hauptverfasser: Sachdeva, Mohit, Duchateau, Philippe, Depil, Stéphane, Poirot, Laurent, Valton, Julien
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2019
Schlagworte:
Accelerated Communications
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6462525/
https://ncbi.nlm.nih.gov/pubmed/30804212
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.AC119.007558
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