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Engineering a Nickase on the Homing Endonuclease I-DmoI Scaffold
Homing endonucleases are useful tools for genome modification because of their capability to recognize and cleave specifically large DNA targets. These endonucleases generate a DNA double strand break that can be repaired by the DNA damage response machinery. The break can be repaired by homologous...
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| 出版年: | J Biol Chem |
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| 主要な著者: | , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
American Society for Biochemistry and Molecular Biology
2015
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4513113/ https://ncbi.nlm.nih.gov/pubmed/26045557 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.658666 |
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