Phosphatidylinositol 4,5-bisphosphate triggers activation of focal adhesion kinase by inducing clustering and conformational changes

Focal adhesion kinase (FAK) is a nonreceptor tyrosine kinase (NRTK) with key roles in integrating growth and cell matrix adhesion signals, and FAK is a major driver of invasion and metastasis in cancer. Cell adhesion via integrin receptors is well known to trigger FAK signaling, and many of the play...

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Autors principals: Goñi, Guillermina M., Epifano, Carolina, Boskovic, Jasminka, Camacho-Artacho, Marta, Zhou, Jing, Bronowska, Agnieszka, Martín, M. Teresa, Eck, Michael J., Kremer, Leonor, Gräter, Frauke, Gervasio, Francesco Luigi, Perez-Moreno, Mirna, Lietha, Daniel
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2014
Matèries:
PNAS Plus
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4128148/
https://ncbi.nlm.nih.gov/pubmed/25049397
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1317022111
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