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Intrinsically active MEK variants are differentially regulated by proteinases and phosphatases
MAPK/ERK kinase (MEK) 1/2 are central signaling proteins that serve as specificity determinants of the MAPK/ERK cascade. More than twenty activating mutations have been reported for MEK1/2, and many of them are known to cause diseases such as cancers, arteriovenous malformation and RASopathies. Chan...
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| Publicat a: | Sci Rep |
|---|---|
| Autors principals: | , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Nature Publishing Group UK
2018
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6081382/ https://ncbi.nlm.nih.gov/pubmed/30087384 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-30202-5 |
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