Conformational transition of FGFR kinase activation revealed by site-specific unnatural amino acid reporter and single molecule FRET

Protein kinases share significant structural similarity; however, structural features alone are insufficient to explain their diverse functions. Thus, bridging the gap between static structure and function requires a more detailed understanding of their dynamic properties. For example, kinase activa...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Perdios, Louis, Lowe, Alan R., Saladino, Giorgio, Bunney, Tom D., Thiyagarajan, Nethaji, Alexandrov, Yuriy, Dunsby, Christopher, French, Paul M. W., Chin, Jason W., Gervasio, Francesco Luigi, Tate, Edward W., Katan, Matilda
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5206623/
https://ncbi.nlm.nih.gov/pubmed/28045057
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep39841
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