Molecular basis of cyclooxygenase enzymes (COXs) selective inhibition

The widely used nonsteroidal anti-inflammatory drugs block the cyclooxygenase enzymes (COXs) and are clinically used for the treatment of inflammation, pain, and cancers. A selective inhibition of the different isoforms, particularly COX-2, is desirable, and consequently a deeper understanding of th...

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Библиографические подробности
Главные авторы: Limongelli, Vittorio, Bonomi, Massimiliano, Marinelli, Luciana, Gervasio, Francesco Luigi, Cavalli, Andrea, Novellino, Ettore, Parrinello, Michele
Формат: Artigo
Язык:Inglês
Опубликовано: National Academy of Sciences 2010
Предметы:
Biological Sciences
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2851773/
https://ncbi.nlm.nih.gov/pubmed/20215464
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0913377107
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