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Mechanistic insight into ligand binding to G-quadruplex DNA
Specific guanine-rich regions in human genome can form higher-order DNA structures called G-quadruplexes, which regulate many relevant biological processes. For instance, the formation of G-quadruplex at telomeres can alter cellular functions, inducing apoptosis. Thus, developing small molecules tha...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Oxford University Press
2014
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4027208/ https://ncbi.nlm.nih.gov/pubmed/24753420 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku247 |
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