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Ligand binding to telomeric G-quadruplex DNA investigated by funnel-metadynamics simulations
G-quadruplexes (G4s) are higher-order DNA structures typically present at promoter regions of genes and telomeres. Here, the G4 formation decreases the replicative DNA at each cell cycle, finally leading to apoptosis. The ability to control this mitotic clock, particularly in cancer cells, is fascin...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5358390/ https://ncbi.nlm.nih.gov/pubmed/28232513 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1612627114 |
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