Identifying Novel Protein-Protein Interactions Using Co-Immunoprecipitation and Mass Spectroscopy

Por Free, R. Benjamin, Hazelwood, Lisa A., Sibley, David R.
Publicado no Curr Protoc Neurosci (2009)

Identification of G Protein-Biased Agonists That Fail To Recruit β-Arrestin or Promote Internalization of the D1 Dopamine Receptor

Por Conroy, Jennie L., Free, R. Benjamin, Sibley, David R.
Publicado no ACS Chem Neurosci (2015)

Advances and Challenges in the Search for D(2) and D(3) Dopamine Receptor-Selective Compounds

Por Moritz, Amy E., Free, R. Benjamin, Sibley, David R.
Publicado no Cell Signal (2017)

Structural basis for Na(+)-sensitivity in dopamine D2 and D3 receptors()

Por Michino, Mayako, Free, R. Benjamin, Doyle, Trevor B., Sibley, David R., Shi, Lei
Publicado no Chem Commun (Camb) (2015)

Reciprocal Modulation of Function between the D(1) and D(2) Dopamine Receptors and the Na(+),K(+)-ATPase

Por Hazelwood, Lisa A., Free, R. Benjamin, Cabrera, David M., Skinbjerg, Mette, Sibley, David R.
Publicado em 2008

cAMP-COUPLED RIBOFLAVIN TRAFFICKING IN PLACENTAL TROPHOBLASTS: A DYNAMIC AND ORDERED PROCESS

Por D’Souza, Vanessa M., Foraker, Amy B., Free, R. Benjamin, Ray, Abhijit, Shapiro, Paul S., Swaan, Peter W.
Publicado em 2006

D(1)-D(2) Dopamine Receptor Synergy Promotes Calcium Signaling via Multiple Mechanisms

Por Chun, Lani S., Free, R. Benjamin, Doyle, Trevor B., Huang, Xi-Ping, Rankin, Michele L., Sibley, David R.
Publicado em 2013

The E(2.65)A mutation disrupts dynamic binding poses of SB269652 at the dopamine D2 and D3 receptors

Por Verma, Ravi Kumar, Abramyan, Ara M., Michino, Mayako, Free, R. Benjamin, Sibley, David R., Javitch, Jonathan A., Lane, J. Robert, Shi, Lei
Publicado no PLoS Comput Biol (2018)

(−)-Stepholidine is a potent pan-dopamine receptor antagonist of both G protein- and β-arrestin-mediated signaling

Por Meade, Julie A., Free, R. Benjamin, Miller, Nicole R., Chun, Lani S., Doyle, Trevor B., Moritz, Amy E., Conroy, Jennie L., Watts, Val J., Sibley, David R.
Publicado no Psychopharmacology (Berl) (2014)

Synthesis and pharmacological characterization of novel trans-cyclopropylmethyl-linked bivalent ligands that exhibit selectivity and allosteric pharmacology at the dopamine D(3) re...

Por Kumar, Vivek, Moritz, Amy E., Keck, Thomas M., Bonifazi, Alessandro, Ellenberger, Michael P., Sibley, Christopher D., Free, R. Benjamin, Shi, Lei, Lane, J. Robert, Sibley, David R., Newman, Amy Hauck
Publicado no J Med Chem (2017)

EXTH-43. DIFFERENTIATED PHARMACOLOGY OF THE IMIPRIDONE ONC201, THE FIRST SELECTIVE DRD2/3 ANTAGONIST IN CLINICAL NEURO-ONCOLOGY

Por Madhukar, Neel, Prabhu, Varun Vijay, Anantharaman, Lakshmi, Sulli, Chidananda, Davidson, Edgar, Deacon, Sean, Tarapore, Rohinton, Rucker, Joseph, Charter, Neil, Doranz, Benjamin, Oster, Wolfgang, Elemento, Olivier, Free, R Benjamin, Sibley, David, Allen, Joshua E
Publicado no Neuro Oncol (2017)

Structure-Activity Investigation of a G Protein-Biased Agonist Reveals Molecular Determinants for Biased Signaling of the D(2) Dopamine Receptor

Por Chun, Lani S., Vekariya, Rakesh H., Free, R. Benjamin, Li, Yun, Lin, Da-Ting, Su, Ping, Liu, Fang, Namkung, Yoon, Laporte, Stephane A., Moritz, Amy E., Aubé, Jeffrey, Frankowski, Kevin J., Sibley, David R.
Publicado no Front Synaptic Neurosci (2018)

Novel Analogues of (R)-5-(Methylamino)-5,6-dihydro-4H-imidazo[4,5,1-ij]quinolin-2(1H)-one (Sumanirole) Provide Clues to Dopamine D(2)/D(3) Receptor Agonist Selectivity

Por Zou, Mu-Fa, Keck, Thomas M., Kumar, Vivek, Donthamsetti, Prashant, Michino, Mayako, Burzynski, Caitlin, Schweppe, Catherine, Bonifazi, Alessandro, Free, R. Benjamin, Sibley, David R., Janowsky, Aaron, Shi, Lei, Javitch, Jonathan A., Newman, Amy Hauck
Publicado no J Med Chem (2016)

DDIS-12. ONC201: THE FIRST SELECTIVE, NON-COMPETITIVE DRD2/3 ANTAGONIST FOR CLINICAL NEURO-ONCOLOGY

Por Vijay Prabhu, Varun, Madhukar, Neel, Anantharaman, Lakshmi, Sulli, Chidananda, Davidson, Edgar, Deacon, Sean, Tarapore, Rohinton, Rucker, Joseph, Charter, Neil, Doranz, Benjamin, Oster, Wolfgang, Stogniew, Martin, Elemento, Olivier, Free, R Benjamin, Sibley, David, Allen, Joshua
Publicado no Neuro Oncol (2018)

Investigation of the binding and functional properties of extended length D(3) dopamine receptor-selective antagonists()

Por Furman, Cheryse A., Roof, Rebecca A., Moritz, Amy E., Miller, Brittney N., Doyle, Trevor B., Free, R. Benjamin, Banala, Ashwini K., Paul, Noel M., Kumar, Vivek, Sibley, Christopher D., Newman, Amy Hauck, Sibley, David R.
Publicado no Eur Neuropsychopharmacol (2014)

Discovery, Optimization, and Characterization of Novel D(2) Dopamine Receptor Selective Antagonists

Por Xiao, Jingbo, Free, R. Benjamin, Barnaeva, Elena, Conroy, Jennie L., Doyle, Trevor, Miller, Brittney, Bryant-Genevier, Marthe, Taylor, Mercedes K., Hu, Xin, Dulcey, Andrés E., Southall, Noel, Ferrer, Marc, Titus, Steve, Zheng, Wei, Sibley, David R., Marugan, Juan J.
Publicado no J Med Chem (2014)

Dopamine D(4) Receptor-Selective Compounds Reveal Structure–Activity Relationships that Engender Agonist Efficacy

Por Keck, Thomas M., Free, R. Benjamin, Day, Marilyn M., Brown, Sonvia L., Maddaluna, Michele S., Fountain, Griffin, Cooper, Charles, Fallon, Brooke, Holmes, Matthew, Stang, Christopher T., Burkhardt, Russell, Bonifazi, Alessandro, Ellenberger, Michael P., Newman, Amy H., Sibley, David R., Wu, Chun, Boateng, Comfort A.
Publicado no J Med Chem (2019)

Identification of Positive Allosteric Modulators of the D(1) Dopamine Receptor That Act at Diverse Binding Sites

Por Luderman, Kathryn D., Conroy, Jennie L., Free, R. Benjamin, Southall, Noel, Ferrer, Marc, Sanchez-Soto, Marta, Moritz, Amy E., Willette, Blair K. A., Fyfe, Tim J., Jain, Prashi, Titus, Steve, Hazelwood, Lisa A., Aubé, Jeffrey, Lane, J. Robert, Frankowski, Kevin J., Sibley, David R.
Publicado no Mol Pharmacol (2018)

EXTH-17. SELECTIVE, NON-COMPETITIVE DRD2/3 ANTAGONISM BY IMIPRIDONE ONC206 IS EFFECTIVE IN TUMORS WITH DOPAMINE RECEPTOR DYSREGULATION

Por Prabhu, Varun Vijay, Madhukar, Neel, Tarapore, Rohinton, Garnett, Mathew, McDermott, Ultan, Benes, Cyril, Anantharaman, Lakshmi, Charter, Neil, Deacon, Sean, VanEngelenburg, Alexander, Rucker, Joseph, Doranz, Benjamin, Rusert, Jessica, Wechsler-Reya, Robert, Elemento, Olivier, Stogniew, Martin, Oster, Wolfgang, DeMorrow, Sharon, Free, R Benjamin, Sibley, David, Allen, Joshua
Publicado no Neuro Oncol (2018)

Discovery and Characterization of a G Protein–Biased Agonist That Inhibits β-Arrestin Recruitment to the D2 Dopamine Receptor

Por Free, R. Benjamin, Chun, Lani S., Moritz, Amy E., Miller, Brittney N., Doyle, Trevor B., Conroy, Jennie L., Padron, Adrian, Meade, Julie A., Xiao, Jingbo, Hu, Xin, Dulcey, Andrés E., Han, Yang, Duan, Lihua, Titus, Steve, Bryant-Genevier, Melanie, Barnaeva, Elena, Ferrer, Marc, Javitch, Jonathan A., Beuming, Thijs, Shi, Lei, Southall, Noel T., Marugan, Juan J., Sibley, David R.
Publicado em 2014