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The E(2.65)A mutation disrupts dynamic binding poses of SB269652 at the dopamine D2 and D3 receptors
The dopamine D2 and D3 receptors (D2R and D3R) are important targets for antipsychotics and for the treatment of drug abuse. SB269652, a bitopic ligand that simultaneously binds both the orthosteric binding site (OBS) and a secondary binding pocket (SBP) in both D2R and D3R, was found to be a negati...
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| Publicado no: | PLoS Comput Biol |
|---|---|
| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5786319/ https://ncbi.nlm.nih.gov/pubmed/29337986 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1005948 |
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