Distinct inactive conformations of the dopamine D2 and D3 receptors correspond to different extents of inverse agonism

By analyzing and simulating inactive conformations of the highly homologous dopamine D(2) and D(3) receptors (D(2)R and D(3)R), we find that eticlopride binds D(2)R in a pose very similar to that in the D(3)R/eticlopride structure but incompatible with the D(2)R/risperidone structure. In addition, r...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:eLife
Main Authors: Lane, J Robert, Abramyan, Ara M, Adhikari, Pramisha, Keen, Alastair C, Lee, Kuo-Hao, Sanchez, Julie, Verma, Ravi Kumar, Lim, Herman D, Yano, Hideaki, Javitch, Jonathan A, Shi, Lei
Format: Artigo
Jezik:Inglês
Izdano: eLife Sciences Publications, Ltd 2020
Teme:
Biochemistry and Chemical Biology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7053997/
https://ncbi.nlm.nih.gov/pubmed/31985399
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.52189
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