Chirality of Novel Bitopic Agonists Determines Unique Pharmacology at the Dopamine D3 Receptor

The dopamine D2/D3 receptor (D(2)R/D(3)R) agonists are used as therapeutics for Parkinson’s disease (PD) and other motor disorders. Selective targeting of D(3)R over D(2)R is attractive because of D(3)R’s restricted tissue distribution with potentially fewer side-effects and its putative neuroprotec...

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Bibliografski detalji
Izdano u:Biomolecules
Glavni autori: Adhikari, Pramisha, Xie, Bing, Semeano, Ana, Bonifazi, Alessandro, Battiti, Francisco O., Newman, Amy H., Yano, Hideaki, Shi, Lei
Format: Artigo
Jezik:Inglês
Izdano: MDPI 2021
Teme:
Brief Report
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8069330/
https://ncbi.nlm.nih.gov/pubmed/33924613
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/biom11040570
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