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The significance of chirality in drug design and synthesis of bitopic ligands as D(3) receptor (D(3)R) selective agonists
Due to the large degree of homology among dopamine D(2)-like receptors, discovering ligands capable of discriminating between the D(2), D(3) and D(4) receptor subtypes remains a significant challenge. Previous work has exemplified the use of bitopic ligands as a powerful strategy in achieving subtyp...
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| 發表在: | J Med Chem |
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| Main Authors: | , , , , , , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2019
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8272914/ https://ncbi.nlm.nih.gov/pubmed/31257877 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.9b00702 |
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