Distinct inactive conformations of the dopamine D2 and D3 receptors correspond to different extents of inverse agonism

By analyzing and simulating inactive conformations of the highly homologous dopamine D(2) and D(3) receptors (D(2)R and D(3)R), we find that eticlopride binds D(2)R in a pose very similar to that in the D(3)R/eticlopride structure but incompatible with the D(2)R/risperidone structure. In addition, r...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Lane, J Robert, Abramyan, Ara M, Adhikari, Pramisha, Keen, Alastair C, Lee, Kuo-Hao, Sanchez, Julie, Verma, Ravi Kumar, Lim, Herman D, Yano, Hideaki, Javitch, Jonathan A, Shi, Lei
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2020
Assuntos:
Biochemistry and Chemical Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7053997/
https://ncbi.nlm.nih.gov/pubmed/31985399
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.52189
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