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The Tetrahydroisoquinoline Derivative SB269,652 Is an Allosteric Antagonist at Dopamine D(3) and D(2) Receptors

In view of the therapeutic importance of dopamine D(3) and D(2) receptors, there remains considerable interest in novel ligands. Herein, we show that the tetrahydroisoquinoline 1H-indole-2-carboxylic acid {4-[2-(cyano-3,4-dihydro-1H-isoquinolin-2-yl)-ethyl]-cyclohexyl}-amide (SB269,652) behaves as a...

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書誌詳細
主要な著者: Silvano, Elena, Millan, Mark J., la Cour, Clotilde Mannoury, Han, Yang, Duan, Lihua, Griffin, Suzy A., Luedtke, Robert R., Aloisi, Gabriella, Rossi, Mario, Zazzeroni, Francesca, Javitch, Jonathan A., Maggio, Roberto
フォーマット: Artigo
言語:Inglês
出版事項: The American Society for Pharmacology and Experimental Therapeutics 2010
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2981362/
https://ncbi.nlm.nih.gov/pubmed/20702763
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.110.065755
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