The Tetrahydroisoquinoline Derivative SB269,652 Is an Allosteric Antagonist at Dopamine D(3) and D(2) Receptors

In view of the therapeutic importance of dopamine D(3) and D(2) receptors, there remains considerable interest in novel ligands. Herein, we show that the tetrahydroisoquinoline 1H-indole-2-carboxylic acid {4-[2-(cyano-3,4-dihydro-1H-isoquinolin-2-yl)-ethyl]-cyclohexyl}-amide (SB269,652) behaves as a...

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Bibliografiset tiedot
Päätekijät: Silvano, Elena, Millan, Mark J., la Cour, Clotilde Mannoury, Han, Yang, Duan, Lihua, Griffin, Suzy A., Luedtke, Robert R., Aloisi, Gabriella, Rossi, Mario, Zazzeroni, Francesca, Javitch, Jonathan A., Maggio, Roberto
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: The American Society for Pharmacology and Experimental Therapeutics 2010
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Articles
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC2981362/
https://ncbi.nlm.nih.gov/pubmed/20702763
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.110.065755
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