The Tetrahydroisoquinoline Derivative SB269,652 Is an Allosteric Antagonist at Dopamine D(3) and D(2) Receptors

In view of the therapeutic importance of dopamine D(3) and D(2) receptors, there remains considerable interest in novel ligands. Herein, we show that the tetrahydroisoquinoline 1H-indole-2-carboxylic acid {4-[2-(cyano-3,4-dihydro-1H-isoquinolin-2-yl)-ethyl]-cyclohexyl}-amide (SB269,652) behaves as a...

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Xehetasun bibliografikoak
Egile Nagusiak: Silvano, Elena, Millan, Mark J., la Cour, Clotilde Mannoury, Han, Yang, Duan, Lihua, Griffin, Suzy A., Luedtke, Robert R., Aloisi, Gabriella, Rossi, Mario, Zazzeroni, Francesca, Javitch, Jonathan A., Maggio, Roberto
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: The American Society for Pharmacology and Experimental Therapeutics 2010
Gaiak:
Articles
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC2981362/
https://ncbi.nlm.nih.gov/pubmed/20702763
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.110.065755
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