The Tetrahydroisoquinoline Derivative SB269,652 Is an Allosteric Antagonist at Dopamine D(3) and D(2) Receptors

In view of the therapeutic importance of dopamine D(3) and D(2) receptors, there remains considerable interest in novel ligands. Herein, we show that the tetrahydroisoquinoline 1H-indole-2-carboxylic acid {4-[2-(cyano-3,4-dihydro-1H-isoquinolin-2-yl)-ethyl]-cyclohexyl}-amide (SB269,652) behaves as a...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Main Authors: Silvano, Elena, Millan, Mark J., la Cour, Clotilde Mannoury, Han, Yang, Duan, Lihua, Griffin, Suzy A., Luedtke, Robert R., Aloisi, Gabriella, Rossi, Mario, Zazzeroni, Francesca, Javitch, Jonathan A., Maggio, Roberto
Format: Artigo
Sprog:Inglês
Udgivet: The American Society for Pharmacology and Experimental Therapeutics 2010
Fag:
Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2981362/
https://ncbi.nlm.nih.gov/pubmed/20702763
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.110.065755
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker