The action of a negative allosteric modulator at the dopamine D(2) receptor is dependent upon sodium ions

Sodium ions (Na(+)) allosterically modulate the binding of orthosteric agonists and antagonists to many class A G protein-coupled receptors, including the dopamine D(2) receptor (D(2)R). Experimental and computational evidences have revealed that this effect is mediated by the binding of Na(+) to a...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Draper-Joyce, Christopher J., Verma, Ravi Kumar, Michino, Mayako, Shonberg, Jeremy, Kopinathan, Anitha, Klein Herenbrink, Carmen, Scammells, Peter J., Capuano, Ben, Abramyan, Ara M., Thal, David M., Javitch, Jonathan A., Christopoulos, Arthur, Shi, Lei, Lane, J. Robert
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5775417/
https://ncbi.nlm.nih.gov/pubmed/29352161
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-19642-1
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados