The action of a negative allosteric modulator at the dopamine D(2) receptor is dependent upon sodium ions

Sodium ions (Na(+)) allosterically modulate the binding of orthosteric agonists and antagonists to many class A G protein-coupled receptors, including the dopamine D(2) receptor (D(2)R). Experimental and computational evidences have revealed that this effect is mediated by the binding of Na(+) to a...

Descripció completa

Guardat en:
Dades bibliogràfiques
Publicat a:Sci Rep
Autors principals: Draper-Joyce, Christopher J., Verma, Ravi Kumar, Michino, Mayako, Shonberg, Jeremy, Kopinathan, Anitha, Klein Herenbrink, Carmen, Scammells, Peter J., Capuano, Ben, Abramyan, Ara M., Thal, David M., Javitch, Jonathan A., Christopoulos, Arthur, Shi, Lei, Lane, J. Robert
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2018
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5775417/
https://ncbi.nlm.nih.gov/pubmed/29352161
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-19642-1
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!

Ítems similars