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Enantioenriched Positive Allosteric Modulators Display Distinct Pharmacology at the Dopamine D(1) Receptor
(1) Background: Two first-in-class racemic dopamine D(1) receptor (D(1)R) positive allosteric modulator (PAM) chemotypes (1 and 2) were identified from a high-throughput screen. In particular, due to its selectivity for the D(1)R and reported lack of intrinsic activity, compound 2 shows promise as a...
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| Udgivet i: | Molecules |
|---|---|
| Main Authors: | , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
MDPI
2021
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8270344/ https://ncbi.nlm.nih.gov/pubmed/34206465 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules26133799 |
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