Identification of Positive Allosteric Modulators of the D(1) Dopamine Receptor That Act at Diverse Binding Sites

The D(1) dopamine receptor is linked to a variety of neuropsychiatric disorders and represents an attractive drug target for the enhancement of cognition in schizophrenia, Alzheimer disease, and other disorders. Positive allosteric modulators (PAMs), with their potential for greater selectivity and...

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Pubblicato in:Mol Pharmacol
Autori principali: Luderman, Kathryn D., Conroy, Jennie L., Free, R. Benjamin, Southall, Noel, Ferrer, Marc, Sanchez-Soto, Marta, Moritz, Amy E., Willette, Blair K. A., Fyfe, Tim J., Jain, Prashi, Titus, Steve, Hazelwood, Lisa A., Aubé, Jeffrey, Lane, J. Robert, Frankowski, Kevin J., Sibley, David R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The American Society for Pharmacology and Experimental Therapeutics 2018
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Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6117505/
https://ncbi.nlm.nih.gov/pubmed/30068735
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.118.113175
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