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Enantioenriched Positive Allosteric Modulators Display Distinct Pharmacology at the Dopamine D(1) Receptor

(1) Background: Two first-in-class racemic dopamine D(1) receptor (D(1)R) positive allosteric modulator (PAM) chemotypes (1 and 2) were identified from a high-throughput screen. In particular, due to its selectivity for the D(1)R and reported lack of intrinsic activity, compound 2 shows promise as a...

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Detalhes bibliográficos
Publicado no:Molecules
Main Authors: Fyfe, Tim J., Scammells, Peter J., Lane, J. Robert, Capuano, Ben
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8270344/
https://ncbi.nlm.nih.gov/pubmed/34206465
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules26133799
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