Molecular Determinants of the Intrinsic Efficacy of the Antipsychotic Aripiprazole

Partial agonists of the dopamine D(2) receptor 18 (D(2)R) have been developed to treat the symptoms of schizophrenia without causing the side effects elicited by antagonists. The receptor–ligand interactions that determine the intrinsic efficacy of such drugs, however, are poorly understood. Aripipr...

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Veröffentlicht in:ACS Chem Biol
Hauptverfasser: Herenbrink, Carmen Klein, Verma, Ravi, Lim, Herman D., Kopinathan, Anitha, Keen, Alastair, Shonberg, Jeremy, Draper-Joyce, Christopher J., Scammells, Peter J., Christopoulos, Arthur, Javitch, Jonathan A., Capuano, Ben, Shi, Lei, Lane, J. Robert
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7365685/
https://ncbi.nlm.nih.gov/pubmed/31339684
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.9b00342
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