EXTH-17. SELECTIVE, NON-COMPETITIVE DRD2/3 ANTAGONISM BY IMIPRIDONE ONC206 IS EFFECTIVE IN TUMORS WITH DOPAMINE RECEPTOR DYSREGULATION

Dopamine receptor D2 (DRD2) is a G protein-coupled receptor that is overexpressed in several cancers and its antagonism has been shown to cause anti-cancer effects. ONC201, an imipridone small molecule, is a DRD2/3 antagonist in Phase II advanced cancer clinical trials. We evaluated the binding targ...

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Veröffentlicht in:Neuro Oncol
Hauptverfasser: Prabhu, Varun Vijay, Madhukar, Neel, Tarapore, Rohinton, Garnett, Mathew, McDermott, Ultan, Benes, Cyril, Anantharaman, Lakshmi, Charter, Neil, Deacon, Sean, VanEngelenburg, Alexander, Rucker, Joseph, Doranz, Benjamin, Rusert, Jessica, Wechsler-Reya, Robert, Elemento, Olivier, Stogniew, Martin, Oster, Wolfgang, DeMorrow, Sharon, Free, R Benjamin, Sibley, David, Allen, Joshua
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2018
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6217127/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy148.366
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