EXTH-74. IND-ENABLING CHARACTERIZATION OF DUAL DRD2- AND ClpP-TARGETING AGENT ONC206 AS THE NEXT IMIPRIDONE FOR CLINICAL NEURO-ONCOLOGY

ONC201 is the first bitopic antagonist of dopamine receptor D2 (DRD2) and allosteric mitochondrial protease ClpP agonist, that is well tolerated and induces durable tumor regressions in H3 K27M-mutant glioma patients. ONC206, a derivative of ONC201, is also a bitopic DRD2 antagonist that exhibits en...

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Vydáno v:Neuro Oncol
Hlavní autoři: Prabhu, Varun, Morrow, Sara, Kawakibi, Abed Rahman, Jitkova, Yulia, Jung, Jinkyu, Madhukar, Neel, Garnett, Mathew, McDermott, Ultan, Benes, Cyril, Wechsler-Reya, Robert, Elemento, Olivier, DeMorrow, Sharon, Schimmer, Aaron, Stogniew, Martin, Theeler, Brett, Gilbert, Mark, Allen, Joshua
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2020
Témata:
Preclinical Experimental Therapeutics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7650984/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa215.428
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