DDRE-33. MOLECULAR DIFFERENTIATION OF IMIPRIDONES ONC201 AND ONC206

ONC201 is the first bitopic antagonist of dopamine receptor D2 (DRD2) and agonist of ClpP in oncology. In clinical trials, the small molecule has induced durable tumor regressions and clinical benefit in H3 K27M-mutant glioma patients while being well tolerated. ONC206 is a chemical derivative of ON...

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Vydáno v:Neuro Oncol
Hlavní autoři: Prabhu, Varun, Cuoco, Caroline, Jung, Jinkyu, Morrow, Sara, Kawakibi, Abed Rahman, Willette, Blair, Day, Marilyn, Anantharaman, Lakshmi, Charter, Neil, Rucker, Joseph, Doranz, Benjamin, Basken, Joel, Stogniew, Martin, Gilbert, Mark, Free, R, Sibley, David, Allen, Joshua
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2020
Témata:
Drug Discovery, Drug Resistance
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7650915/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa215.278
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