ONC201 and imipridones: Anti-cancer compounds with clinical efficacy

ONC201 was originally discovered as TNF-Related Apoptosis Inducing Ligand (TRAIL)-inducing compound TIC10. ONC201 appears to act as a selective antagonist of the G protein coupled receptor (GPCR) dopamine receptor D2 (DRD2), and as an allosteric agonist of mitochondrial protease caseinolytic proteas...

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Foilsithe in:Neoplasia
Main Authors: Prabhu, Varun Vijay, Morrow, Sara, Rahman Kawakibi, Abed, Zhou, Lanlan, Ralff, Marie, Ray, Jocelyn, Jhaveri, Aakash, Ferrarini, Isacco, Lee, Young, Parker, Cassandra, Zhang, Yiqun, Borsuk, Robyn, Chang, Wen-I, Honeyman, Joshua N., Tavora, Fabio, Carneiro, Benedito, Raufi, Alexander, Huntington, Kelsey, Carlsen, Lindsey, Louie, Anna, Safran, Howard, Seyhan, Attila A., Tarapore, Rohinton S., Schalop, Lee, Stogniew, Martin, Allen, Joshua E., Oster, Wolfgang, El-Deiry, Wafik S.
Formáid: Artigo
Teanga:Inglês
Foilsithe: Neoplasia Press 2020
Ábhair:
Review article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7588802/
https://ncbi.nlm.nih.gov/pubmed/33142238
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neo.2020.09.005
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