ONC201 and imipridones: Anti-cancer compounds with clinical efficacy

ONC201 was originally discovered as TNF-Related Apoptosis Inducing Ligand (TRAIL)-inducing compound TIC10. ONC201 appears to act as a selective antagonist of the G protein coupled receptor (GPCR) dopamine receptor D2 (DRD2), and as an allosteric agonist of mitochondrial protease caseinolytic proteas...

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Bibliografische gegevens
Gepubliceerd in:Neoplasia
Hoofdauteurs: Prabhu, Varun Vijay, Morrow, Sara, Rahman Kawakibi, Abed, Zhou, Lanlan, Ralff, Marie, Ray, Jocelyn, Jhaveri, Aakash, Ferrarini, Isacco, Lee, Young, Parker, Cassandra, Zhang, Yiqun, Borsuk, Robyn, Chang, Wen-I, Honeyman, Joshua N., Tavora, Fabio, Carneiro, Benedito, Raufi, Alexander, Huntington, Kelsey, Carlsen, Lindsey, Louie, Anna, Safran, Howard, Seyhan, Attila A., Tarapore, Rohinton S., Schalop, Lee, Stogniew, Martin, Allen, Joshua E., Oster, Wolfgang, El-Deiry, Wafik S.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Neoplasia Press 2020
Onderwerpen:
Review article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7588802/
https://ncbi.nlm.nih.gov/pubmed/33142238
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neo.2020.09.005
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