DDIS-08. THE SMALL MOLECULE IMIPRIDONE ONC201 IS ACTIVE IN GLIOBLASTOMA WITH DRD2 PATHWAY DYSREGULATION

ONC201, an imipridone that is a selective antagonist of the G protein-coupled receptors dopamine receptor D2 (DRD2) and D3 (DRD3), has exhibited tumor shrinkage and an exceptional safety profile in a phase II recurrent glioblastoma clinical trial (Arrillaga et al, 2017). In vitro and in vivo studies...

Ful tanımlama

Kaydedildi:
Detaylı Bibliyografya
Yayımlandı:Neuro Oncol
Asıl Yazarlar: Prabhu, Varun Vijay, Madhukar, Neel, Kline, C Leah B, Tarapore, Rohinton S, El-Deiry, Wafik, Elemento, Olivier, Rucker, Joseph, Doranz, Benjamin, Doherty, Faye, VanEngelenburg, Alexander, Durrant, Jessica, Benes, Cyril, Arrillaga-Romany, Isabel, Oster, Wolfgang, Allen, Joshua E
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Oxford University Press 2017
Konular:
Abstracts
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5693016/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox168.244
Etiketler: Etiketle
Etiket eklenmemiş, İlk siz ekleyin!

Benzer Materyaller