EXTH-71. IND-ENABLING CHARACTERIZATION OF ONC206 AS THE NEXT BITOPIC DRD2 ANTAGONIST FOR NEURO-ONCOLOGY

ONC201 is the first clinical bitopic antagonist of DRD2, an oncogenic receptor in brain and neuroendocrine tumors. ONC206, a derivative of ONC201 that shares the imipridone core structure, is also a bitopic DRD2 antagonist that exhibits enhanced non-competitive effects, high specificity, nanomolar p...

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Detalhes bibliográficos
Publicado no:Neuro Oncol
Main Authors: Prabhu, Varun, Rahman Kawakibi, Abed, Madhukar, Neel, Garnett, Mathew, McDermott, Ultan, Benes, Cyril, Wechsler-Reya, Robert, Elemento, Olivier, Stogniew, Martin, Oster, Wolfgang, DeMorrow, Sharon, Allen, Joshua
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2019
Assuntos:
Experimental Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6846353/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz175.401
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