Dopamine D(4) Receptor-Selective Compounds Reveal Structure–Activity Relationships that Engender Agonist Efficacy

[Image: see text] The dopamine D(4) receptor (D(4)R) plays important roles in cognition, attention, and decision making. Novel D(4)R-selective ligands have promise in medication development for neuropsychiatric conditions, including Alzheimer’s disease and substance use disorders. To identify new D(...

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Publicado no:J Med Chem
Main Authors: Keck, Thomas M., Free, R. Benjamin, Day, Marilyn M., Brown, Sonvia L., Maddaluna, Michele S., Fountain, Griffin, Cooper, Charles, Fallon, Brooke, Holmes, Matthew, Stang, Christopher T., Burkhardt, Russell, Bonifazi, Alessandro, Ellenberger, Michael P., Newman, Amy H., Sibley, David R., Wu, Chun, Boateng, Comfort A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2019
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6466480/
https://ncbi.nlm.nih.gov/pubmed/30883109
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.9b00231
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