Towards Antitumor Active trans-Platinum Compounds

Tekijä Aris, Sheena M., Farrell, Nicholas P.
Julkaistu 2009

Excursions in polynuclear platinum DNA binding

Tekijä Mangrum, John B., Farrell, Nicholas P.
Julkaistu 2010

Substitution-inert trinuclear platinum complexes efficiently condense/aggregate nucleic acids and inhibit enzymatic activity

Tekijä Malina, Jaroslav, Farrell, Nicholas P., Brabec, Viktor
Julkaisussa Angew Chem Int Ed Engl (2014)

Substitution-inert polynuclear platinum complexes inhibit activity of DNA polymerase in triplex-forming templates

Tekijä Malina, Jaroslav, Farrell, Nicholas P., Brabec, Viktor
Julkaisussa Angew Chem Int Ed Engl (2018)

Structural consequences of a 3′ → 3′ DNA interstrand cross-link by a trinuclear platinum complex: unique formation of two such cross-links in a 10-mer duplex

Tekijä Qu, Yun, Tran, My-Chau, Farrell, Nicholas P.
Julkaistu 2009

Walking of antitumor bifunctional trinuclear Pt(II) complex on double-helical DNA

Tekijä Malina, Jaroslav, Kasparkova, Jana, Farrell, Nicholas P., Brabec, Viktor
Julkaistu 2011

PLATINUM-BASED DRUGS AND PROTEINS: REACTIVITY AND RELEVANCE TO DNA ADDUCT FORMATION

Tekijä Pinato, Odra, Musetti, Caterina, Farrell, Nicholas P., Sissi, Claudia
Julkaistu 2013

Inhibition of nuclear factor kappaB proteins-platinated DNA interactions correlates with cytotoxic effectiveness of the platinum complexes

Tekijä Brabec, Viktor, Kasparkova, Jana, Kostrhunova, Hana, Farrell, Nicholas P.
Julkaisussa Sci Rep (2016)

Dinuclear Platinum Complexes Containing Planar Aromatic Ligands to Enhance Stacking Interactions with Proteins

Tekijä Ma, Erin S. F., Daniel, A.G., Farrell, Nicholas P.
Julkaisussa ChemMedChem (2014)

Competitive formation of both long-range 5´–5´ and short-range antiparallel 3´–3´ DNA interstrand cross-links by a trinuclear platinum complex on binding to a 10-mer duplex

Tekijä Ruhayel, Rasha A., Berners-Price, Susan J., Farrell, Nicholas P.
Julkaistu 2012

Biological relevance of interaction of platinum drugs with O-donor ligands

Tekijä Gorle, Anil K., Berners-Price, Susan J., Farrell, Nicholas P.
Julkaisussa Inorganica Chim Acta (2019)

Solution studies of dinuclear polyamine-linked platinum-based antitumour complexes

Tekijä Ruhayel, Rasha A., Zgani, Ibrahim, Berners-Price, Susan J., Farrell, Nicholas P.
Julkaistu 2011

Molecular methods for assessment of non-covalent metallodrug–DNA interactions

Tekijä Kellett, Andrew, Molphy, Zara, Slator, Creina, McKee, Vickie, Farrell, Nicholas P.
Julkaisussa Chem Soc Rev (2019)

Influence of geometric isomerism on the binding of platinum anticancer agents with phospholipids

Tekijä Gorle, Anil Kumar, Zhang, Junyong, Berners-Price, Susan J., Farrell, Nicholas P.
Julkaisussa Dalton Trans (2019)

Conformation and recognition of DNA modified by a new antitumor dinuclear Pt(II) complex resistant to decomposition by sulfur nucleophiles

Tekijä Zerzankova, Lenka, Suchankova, Tereza, Vrana, Oldrich, Farrell, Nicholas P., Brabec, Viktor, Kasparkova, Jana
Julkaistu 2009

Amide-Based Prodrugs of Spermidine-Bridged Dinuclear Platinum. Synthesis, DNA Binding, and Biological Activity

Tekijä Hegmans, Alexander, Kasparkova, Jana, Vrana, Oldrich, Kelland, Lloyd R., Brabec, Viktor, Farrell, Nicholas P.
Julkaistu 2008

Effects of Noncovalent Platinum Drug–Protein Interactions on Drug Efficacy: Use of Fluorescent Conjugates as Probes for Drug Metabolism

Tekijä Benedetti, Brad T., Peterson, Erica J., Kabolizadeh, Peyman, Martínez, Alberto, Kipping, Ralph, Farrell, Nicholas P.
Julkaistu 2011

Ligand modulation of a dinuclear platinum compound leads to mechanistic differences in cell cycle progression and arrest

Tekijä Menon, Vijay R., Peterson, Erica J., Valerie, Kristoffer, Farrell, Nicholas P., Povirk, Lawrence F.
Julkaistu 2013

Competitive formation of DNA linkage isomers by a trinuclear platinum complex and the influence of pre-association

Tekijä Moniodis, Joseph J., Thomas, Donald S., Davies, Murray S., Berners-Price, Susan J., Farrell, Nicholas P.
Julkaisussa Dalton Trans (2015)

Polynuclear platinum anticancer drugs are more potent than cisplatin and induce cell cycle arrest in glioma

Tekijä Billecke, Christine, Finniss, Susan, Tahash, Laura, Miller, Cathie, Mikkelsen, Tom, Farrell, Nicholas P., Bögler, Oliver
Julkaistu 2006