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Competitive formation of DNA linkage isomers by a trinuclear platinum complex and the influence of pre-association

2D [(1)H, (15)N] HSQC NMR spectroscopy has been used to monitor the reaction of fully (15)N-labelled [{trans-PtCl(NH(3))(2)}(2)(μ-trans-Pt(NH(3))(2) {NH(2)(CH(2))(6)NH(2)}(2))](4+) (BBR3464 ((15)N-1)) with the 14-mer duplex (5’-{d(ATACATG(7)G(8)TACATA)}-3’. 5’-{d(TATG(18)TACCATG(25)TAT)}-3’ or I) at...

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Publicado en:Dalton Trans
Autores principales: Moniodis, Joseph J., Thomas, Donald S., Davies, Murray S., Berners-Price, Susan J., Farrell, Nicholas P.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2015
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4324329/
https://ncbi.nlm.nih.gov/pubmed/25407024
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c4dt02942a
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