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Substitution-inert polynuclear platinum complexes inhibit activity of DNA polymerase in triplex-forming templates
The formation of triple-helical DNA is implicated in the regulation of gene expression. The triplexes are, however, unstable under physiological conditions so that effective stabilizers for the triplex formation are needed. Here, we describe a new strategy for stabilization of the triplexes based on...
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| Опубликовано в: : | Angew Chem Int Ed Engl |
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| Главные авторы: | , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2018
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6625320/ https://ncbi.nlm.nih.gov/pubmed/29766623 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201803448 |
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