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Substitution-inert polynuclear platinum complexes inhibit activity of DNA polymerase in triplex-forming templates

The formation of triple-helical DNA is implicated in the regulation of gene expression. The triplexes are, however, unstable under physiological conditions so that effective stabilizers for the triplex formation are needed. Here, we describe a new strategy for stabilization of the triplexes based on...

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Publicat a:Angew Chem Int Ed Engl
Autors principals: Malina, Jaroslav, Farrell, Nicholas P., Brabec, Viktor
Format: Artigo
Idioma:Inglês
Publicat: 2018
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6625320/
https://ncbi.nlm.nih.gov/pubmed/29766623
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201803448
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