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Amide-Based Prodrugs of Spermidine-Bridged Dinuclear Platinum. Synthesis, DNA Binding, and Biological Activity
The chemistry and biology of acetyl-protected spermidine-bridged dinuclear platinum complexes [{trans-PtCl(NH(3))(2)](2)-μ-NH(2)(CH(2))(3)N(COR)(CH(2))(4)NH(2)]X(2) (R = H, X = Cl (1,1/t,t-spermidine, BBR3571); R = CH(3,) X = Cl (2); R = CH(2) Cl, X = ClO(4) (3); R = CF(3,) X = Cl (4)) are compared...
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| Autori principali: | , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2008
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2803320/ https://ncbi.nlm.nih.gov/pubmed/18338842 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm070813z |
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